Deprivation indices are widely used to identify areas characterized by above average social and/or material disadvantages. Especially spatial approaches have become increasingly popular since they enable decision makers to identify priority areas and to allocate their resources accordingly. An array of methods and spatial reporting units have been used to analyze and report deprivation in previous studies. However, a comparative analysis and assessment of the implications of the choice of the reporting unit for quality of life and health care accessibility planning is still missing. Based on a set of ten socioeconomic and health-related indicators, we constructed a weighted deprivation index for the urban area of Quito, Ecuador, using four different reporting units, including census blocks, census tracts, and two units based on the automatic zoning procedure (AZP).