| Sumario: | Globalization and free markets are relevant aspects for the decision-making of nations and their productive apparatus, where innovation is the main component to stimulate competitiveness and achieve sustainable development goals. This article analyses design methodologies for innovation and their relationship with the competitiveness of companies in the textile and clothing sector in Medellín. The objective of the study is to describe and explain the relationship that exists between design methodologies for innovation and the competitiveness of small and medium-sized companies in the textile and clothing sector in Medellín and its scope in economic results. For methodological purposes, a discrete and representative election model is used on a sample of small and medium-sized companies in the textile sector of Medellín, in which a survey-type instrument is applied, designed and tested to achieve the purposes of information management. The research has a mixed approach, descriptive explanatory, creating the need to study the application of design methodologies for the generation of business innovation. The study findings indicate that there is a 64.3 relationship percentage between design methodologies for innovation and the competitiveness of the companies that are part of this analysis, and a 62.05 relationship percentage between design methodologies for innovation and the results of the business activity expressed in terms of sales, market share, profitability and corporate image.
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