Biblioteca Digital de VanguardiaAged garlic extract enhances paraoxonase 1 activity and suppress oxidative stress in CCl4 - intoxicated rats
The current study was undertaken to evaluate the hepatoprotective potential of aged garlicextract (AGE) against hepatotoxicity induced by CCl4 in adult male rats. CCl4 intoxication (1ml/kg b.w., twice a week, i.p. for 4 weeks) significantly increased oxidative stress as indicated byincreased hepatic...
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| Formato: | info:eu-repo/semantics/article |
| Lenguaje: | Portugués |
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Federal University of Piauí
2012
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| Acceso en línea: | https://comunicatascientiae.com.br/comunicata/article/view/95 http://biblioteca-repositorio.clacso.edu.ar/handle/CLACSO/77522 |
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| author | Abdel-Wahhab, Khaled Gamal El-Deen Khadrawy, Yasser Ashry Mannaa, Fathia Abd Elwahid |
| author_facet | Abdel-Wahhab, Khaled Gamal El-Deen Khadrawy, Yasser Ashry Mannaa, Fathia Abd Elwahid |
| author_sort | Abdel-Wahhab, Khaled Gamal El-Deen |
| collection | Repositorio |
| description | The current study was undertaken to evaluate the hepatoprotective potential of aged garlicextract (AGE) against hepatotoxicity induced by CCl4 in adult male rats. CCl4 intoxication (1ml/kg b.w., twice a week, i.p. for 4 weeks) significantly increased oxidative stress as indicated byincreased hepatic MDA formation, decreased both serum total and reduced glutathione contents,and inhibition of hepatic glutathione reductase and serum paraoxonase 1(POX1) activities. Inaddition, treatment with CCl4 produced a significant increase in the activities of serum ALT, ASTand albumin level with a significant decrease in total protein level. Moreover, treatment with CCl4resulted in significant increase in the levels of total cholesterol, LDL-cholesterol, triglycerides as wellas creatine kinase isoenzyme and lactate dehydrogenase activities, and a significant decrease inHDL-cholesterol compared to control group. Oral treatment with AGE at doses of 100 and 200 mg/kg/day in combination with CCl4 significantly ameliorated the severity of CCl4- induced changes inthe above mentioned parameters in a dose- dependent manner. In conclusion, the present studyindicated that AGE improves POX1 activity and attenuates liver and cardiac dysfunction inducedby CCl4. The protective effects of AGE against CCl4 toxicity may be attributed to its antioxidant andfree radical scavenging activities due to its higher contents of organosulphur compounds. |
| format | info:eu-repo/semantics/article |
| id | clacso-CLACSO77522 |
| institution | CLACSO, Repositorio Digital |
| language | Portugués |
| publishDate | 2012 |
| publisher | Federal University of Piauí |
| record_format | greenstone |
| spelling | clacso-CLACSO775222022-03-21T20:06:57Z Aged garlic extract enhances paraoxonase 1 activity and suppress oxidative stress in CCl4 - intoxicated rats Extrato envelhecido de alho incrementa a atividade de paraoxonase 1 e suprime o estresse oxidativo em ratos intoxicados com CCl4 - Abdel-Wahhab, Khaled Gamal El-Deen Khadrawy, Yasser Ashry Mannaa, Fathia Abd Elwahid Garlic hepatotoxicity CCl4 heart function antioxidant The current study was undertaken to evaluate the hepatoprotective potential of aged garlicextract (AGE) against hepatotoxicity induced by CCl4 in adult male rats. CCl4 intoxication (1ml/kg b.w., twice a week, i.p. for 4 weeks) significantly increased oxidative stress as indicated byincreased hepatic MDA formation, decreased both serum total and reduced glutathione contents,and inhibition of hepatic glutathione reductase and serum paraoxonase 1(POX1) activities. Inaddition, treatment with CCl4 produced a significant increase in the activities of serum ALT, ASTand albumin level with a significant decrease in total protein level. Moreover, treatment with CCl4resulted in significant increase in the levels of total cholesterol, LDL-cholesterol, triglycerides as wellas creatine kinase isoenzyme and lactate dehydrogenase activities, and a significant decrease inHDL-cholesterol compared to control group. Oral treatment with AGE at doses of 100 and 200 mg/kg/day in combination with CCl4 significantly ameliorated the severity of CCl4- induced changes inthe above mentioned parameters in a dose- dependent manner. In conclusion, the present studyindicated that AGE improves POX1 activity and attenuates liver and cardiac dysfunction inducedby CCl4. The protective effects of AGE against CCl4 toxicity may be attributed to its antioxidant andfree radical scavenging activities due to its higher contents of organosulphur compounds. O presente estudo foi realizado para avaliar o potencial hepatoprotetor do extrato de alhoenvelhecido (AGE) contra hepatotoxicidade induzida por CCl4 em ratos machos adultos. CCl4intoxicação (1ml/Kg no peso corporal, duas vezes por semana, ip durante 4 semanas) aumentousignificativamente o Estresse oxidativo, tal como indicado pelo aumento da formação de MDAhepática, diminuição tanto de soro total e conteúdo de glutationa, e inibição da atividade deglutationa redutase hepática e paraoxonase soro 1 (POX1 ). Além disso, o tratamento com CCl4produziu um aumento significativo nas atividades séricas de ALT, AST e nível de albumina comuma diminuição significativa no nível de proteína total. Ademais, o tratamento com CCl4 resultounum aumento significativo dos níveis de colesterol total, colesterol-LDL, triglicerídeos, bem comoisoenzima creatina quinase e atividades da lactato desidrogenase, e uma diminuição significativanos níveis de HDL-colesterol, se comparado com o grupo controle. O tratamento oral com AGE emdoses de 100 e 200 mg / kg / dia em combinação com CCl4 demonstrou melhoras significativas nagravidade das alterações de CCl4 induzidas nos parâmetros acima mencionados, de uma maneiradose-dependente. Em conclusão, o presente estudo indicou que a idade aumenta a atividadede POX1 e atenua a disfunção no fígado e no coração induzidas por CCl4. Os efeitos protetoresde idade contra a CCl4 toxicidade podem ser atribuídos aos seus antioxidantes e radicais livres,devido aos elevados teores de compostos organosulfurados. 2012-03-30 2022-03-21T20:06:57Z 2022-03-21T20:06:57Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://comunicatascientiae.com.br/comunicata/article/view/95 10.14295/cs.v3i1.95 http://biblioteca-repositorio.clacso.edu.ar/handle/CLACSO/77522 por https://comunicatascientiae.com.br/comunicata/article/view/95/96 https://comunicatascientiae.com.br/comunicata/article/view/95/621 application/pdf application/msword Federal University of Piauí Comunicata Scientiae; Vol. 3 No. 1 (2012); 55-63 Comunicata Scientiae; v. 3 n. 1 (2012); 55-63 2177-5133 2176-9079 |
| spellingShingle | Garlic hepatotoxicity CCl4 heart function antioxidant Abdel-Wahhab, Khaled Gamal El-Deen Khadrawy, Yasser Ashry Mannaa, Fathia Abd Elwahid Aged garlic extract enhances paraoxonase 1 activity and suppress oxidative stress in CCl4 - intoxicated rats |
| title | Aged garlic extract enhances paraoxonase 1 activity and suppress oxidative stress in CCl4 - intoxicated rats |
| title_full | Aged garlic extract enhances paraoxonase 1 activity and suppress oxidative stress in CCl4 - intoxicated rats |
| title_fullStr | Aged garlic extract enhances paraoxonase 1 activity and suppress oxidative stress in CCl4 - intoxicated rats |
| title_full_unstemmed | Aged garlic extract enhances paraoxonase 1 activity and suppress oxidative stress in CCl4 - intoxicated rats |
| title_short | Aged garlic extract enhances paraoxonase 1 activity and suppress oxidative stress in CCl4 - intoxicated rats |
| title_sort | aged garlic extract enhances paraoxonase 1 activity and suppress oxidative stress in ccl4 - intoxicated rats |
| topic | Garlic hepatotoxicity CCl4 heart function antioxidant |
| url | https://comunicatascientiae.com.br/comunicata/article/view/95 http://biblioteca-repositorio.clacso.edu.ar/handle/CLACSO/77522 |