Biblioteca Digital de VanguardiaProtective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats
The present study was conducted to study the chemoprotective effect of Egyptian rosemary extract (RE) against CCl4-induced hepatotoxicity. Eight experimental groups were used as follow: (1) control; (2&3) RE alone (440 mg/kgb.w) for 4 and 8 weeks, respectively; (4) CCl4 (1ml/kg b.w, twice a week...
| Autores principales: | , , , , |
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| Formato: | info:eu-repo/semantics/article |
| Lenguaje: | Portugués |
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Federal University of Piauí
2011
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| Acceso en línea: | https://comunicatascientiae.com.br/comunicata/article/view/82 http://biblioteca-repositorio.clacso.edu.ar/handle/CLACSO/77514 |
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| author | Abdel-Wahhab, Khaled Gamal El-Deen El-Shamy, Karima Abbas El-Beih, Nadia Abd El-Zizz Morcy, Fatma Adly Mannaa, Fathia Abd Elwahid |
| author_facet | Abdel-Wahhab, Khaled Gamal El-Deen El-Shamy, Karima Abbas El-Beih, Nadia Abd El-Zizz Morcy, Fatma Adly Mannaa, Fathia Abd Elwahid |
| author_sort | Abdel-Wahhab, Khaled Gamal El-Deen |
| collection | Repositorio |
| description | The present study was conducted to study the chemoprotective effect of Egyptian rosemary extract (RE) against CCl4-induced hepatotoxicity. Eight experimental groups were used as follow: (1) control; (2&3) RE alone (440 mg/kgb.w) for 4 and 8 weeks, respectively; (4) CCl4 (1ml/kg b.w, twice a week, i.p) for 4 weeks; (5&7) RE (220&440 mg/kg) for 4 weeks before CCl4 for a similar period; and (6&8) RE (220&440 mg/kg) for four weeks before CCl4 in combination with RE another four weeks. The sequential CCl4 treatment induced significant changes in serum biochemical parameters accompanied by sever histological and histochemical changes of the liver tissue, while administration of 440 mg/kg/day for either 4 or 8 weeks did not induce any changes. Administration of RE before or during the treatment with CCl4 improved all biochemical parameters and histological picture of the liver, in a dose and duration-dependant manner. It could be concluded that RE has a protective effects against hepatotoxicity. |
| format | info:eu-repo/semantics/article |
| id | clacso-CLACSO77514 |
| institution | CLACSO, Repositorio Digital |
| language | Portugués |
| publishDate | 2011 |
| publisher | Federal University of Piauí |
| record_format | greenstone |
| spelling | clacso-CLACSO775142022-03-21T20:06:56Z Protective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats Protective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats Abdel-Wahhab, Khaled Gamal El-Deen El-Shamy, Karima Abbas El-Beih, Nadia Abd El-Zizz Morcy, Fatma Adly Mannaa, Fathia Abd Elwahid Rosemary extract hepatotoxicity carbon tetrachloride liver function Rosemary extract hepatotoxicity carbon tetrachloride liver function The present study was conducted to study the chemoprotective effect of Egyptian rosemary extract (RE) against CCl4-induced hepatotoxicity. Eight experimental groups were used as follow: (1) control; (2&3) RE alone (440 mg/kgb.w) for 4 and 8 weeks, respectively; (4) CCl4 (1ml/kg b.w, twice a week, i.p) for 4 weeks; (5&7) RE (220&440 mg/kg) for 4 weeks before CCl4 for a similar period; and (6&8) RE (220&440 mg/kg) for four weeks before CCl4 in combination with RE another four weeks. The sequential CCl4 treatment induced significant changes in serum biochemical parameters accompanied by sever histological and histochemical changes of the liver tissue, while administration of 440 mg/kg/day for either 4 or 8 weeks did not induce any changes. Administration of RE before or during the treatment with CCl4 improved all biochemical parameters and histological picture of the liver, in a dose and duration-dependant manner. It could be concluded that RE has a protective effects against hepatotoxicity. The present study was conducted to study the chemoprotective effect of Egyptian rosemary extract (RE) against CCl4-induced hepatotoxicity. Eight experimental groups were used as follow: (1) control; (2&3) RE alone (440 mg/kgb.w) for 4 and 8 weeks, respectively; (4) CCl4 (1ml/kg b.w, twice a week, i.p) for 4 weeks; (5&7) RE (220&440 mg/kg) for 4 weeks before CCl4 for a similar period; and (6&8) RE (220&440 mg/kg) for four weeks before CCl4 in combination with RE another four weeks. The sequential CCl4 treatment induced significant changes in serum biochemical parameters accompanied by sever histological and histochemical changes of the liver tissue, while administration of 440 mg/kg/day for either 4 or 8 weeks did not induce any changes. Administration of RE before or during the treatment with CCl4 improved all biochemical parameters and histological picture of the liver, in a dose and duration-dependant manner. It could be concluded that RE has a protective effects against hepatotoxicity. Efeito protetor de erva natural (Rosmarinus officinalis) contrahepatotoxicidade em ratos albinos machosResumoO presente estudo foi realizado para verificar o efeito quimioprotetor do extrato de alecrim egípcio(RE) contra toxidade hepática induzida por CCl4-. Oito grupos experimentais foram utilizados, comosegue: (1) controle; (2&3) apenas RE (440 mg/kgb.w) por 4 e 8 semanas, respectivamente; (4) CCl4(1ml/kg b.w, duas vezes por semana, i.p) durante 4 semanas; (5&7) RE (220&440 mg/kg) por quatrosemanas antes de CCl4 por um período similar; e(6&8) RE (220&440 mg/kg) por quatro semanasantes de CCl4 combinado com RE por outras quatro semanas. O tratamento seqüencial de CCl4induziu mudanças significativas nos parâmetros bioquímicos do soro, acompanhadas por severasmudanças histológicas e histoquímicas no tecido do fígado, enquanto que a administração de 440mg/kg/dia durante 4 ou 8 semanas não induziu nenhuma mudança. A administração de RE antesou durante o tratamento com CCl4 aumentou os parâmetros bioquímicos e histológicos do fígado,dependendo da dose e de sua duração. Pode-se concluir que RE apresenta efeito de proteçãocontra a toxidade hepática. 2011-04-19 2022-03-21T20:06:56Z 2022-03-21T20:06:56Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://comunicatascientiae.com.br/comunicata/article/view/82 10.14295/cs.v2i1.82 http://biblioteca-repositorio.clacso.edu.ar/handle/CLACSO/77514 por https://comunicatascientiae.com.br/comunicata/article/view/82/59 application/pdf Federal University of Piauí Comunicata Scientiae; Vol. 2 No. 1 (2011); 9-17 Comunicata Scientiae; v. 2 n. 1 (2011); 9-17 2177-5133 2176-9079 |
| spellingShingle | Rosemary extract hepatotoxicity carbon tetrachloride liver function Rosemary extract hepatotoxicity carbon tetrachloride liver function Abdel-Wahhab, Khaled Gamal El-Deen El-Shamy, Karima Abbas El-Beih, Nadia Abd El-Zizz Morcy, Fatma Adly Mannaa, Fathia Abd Elwahid Protective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats |
| title | Protective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats |
| title_full | Protective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats |
| title_fullStr | Protective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats |
| title_full_unstemmed | Protective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats |
| title_short | Protective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats |
| title_sort | protective effect of a natural herb (rosmarinus officinalis) against hepatotoxicity in male albino rats |
| topic | Rosemary extract hepatotoxicity carbon tetrachloride liver function Rosemary extract hepatotoxicity carbon tetrachloride liver function |
| url | https://comunicatascientiae.com.br/comunicata/article/view/82 http://biblioteca-repositorio.clacso.edu.ar/handle/CLACSO/77514 |